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Alcohol to Triflate

Common Conditions:


The formation of triflates with trifluoromethanesulfonic anhydride (Tf2O) is usually accomplished with a base (ex. TEA or pyridine), in a solvent such as DCM, with cooling or at RT.[1]


N-Phenylbis(trifluoromethanesufonimide) (TF2NPh) is a milder triflating reagent than Tf2O. In certain cases it can provide better selectivity.

Reaction Map:

The reaction map is intended to provide insight into possible reactions one step before and after the title reaction. It also serves as an alternative way to navigate the website, and as a means of coming up with retrosynthetic ideas. Click on the reaction arrow to visit the page.



1) Pearson, A. J.; Roush, W. R.; Handbook of Reagents for Organic Synthesis, Activating Agents and Protecting Groups