DCM

(Dichloromethane)

Other Names:

Methylene chloride

General Information:

Structure:

CAS Number: 75-09-2

Molecular Weight: 84.93 g/mol

Appearance: Colorless liquid

Chemical Formula: CH2Cl2

Melting Point: -95 C

Boiling Point: 40 C

Density: 1.33 g/mL

Common Uses:

Solvent for reactions

Procedure excerpt:

To a solution of the SM (300 mg, 2.30 mmol) in DCM (6 mL) at 0 C was added TEA (0.64 mL, 4.6 mmol) followed by MeSO2Cl (0.21 mL, 2.76 mmol). The reaction mixture was . . .

[full procedure]

Solvent for extractions

Procedure excerpt:

. . . The resulting mixture was extracted with DCM (2 x 200 mL). The combined extracts were dried (Na2SO4) and concentrated . . .

[full procedure]

Solvent for silica gel chromatography

Procedure excerpt:

. . . The crude product was purified by silica gel column chromatography (0-10% MeOH/DCM) to provide the product . . .

[full procedure]

Safety:

Dichloromethane (DCM) is considered toxic and may be a carcinogen. Prolonged contact with skin can dissolve fatty tissues and cause burns. The high volatility of DCM makes it a possible inhalation hazard. DCM is only considered to be slightly flammable.

References:

1) Patent Reference: WO2015129926, page 89, (21.5 MB)

2) Patent Reference: WO2012129338, page 134, (12.0 MB)

3) Patent Reference: WO2015051043, page 60, (9.7 MB)

4) Wikipedia: Dichloromethane (link)

5) www.sigmaaldrich.com: Dichloromethane (link)