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Other Names:

Methylene chloride

General Information:


CAS Number: 75-09-2

Molecular Weight: 84.93 g/mol

Appearance: Colorless liquid

Chemical Formula: CH2Cl2

Melting Point: -95 C

Boiling Point: 40 C

Density: 1.33 g/mL

Common Uses:

Solvent for reactions

Solvent for extractions

Procedure excerpt:

…The resulting mixture was extracted with DCM (2 x 200 mL). The combined extracts were dried (Na2SO4) and concentrated…

Solvent for silica gel chromatography

Procedure excerpt:

...The crude product was purified by silica gel column chromatography (0-10% MeOH/DCM) to provide the product...


Dichloromethane (DCM) is considered toxic and may be a carcinogen. Prolonged contact with skin can dissolve fatty tissues and cause burns. The high volatility of DCM makes it a possible inhalation hazard. DCM is only considered to be slightly flammable.


1) Patent Reference: WO2015129926, page 89, (21.5 MB)

2) Patent Reference: WO2012129338, page 134, (12.0 MB)

3) Patent Reference: WO2015051043, page 60, (9.7 MB)

4) Wikipedia: Dichloromethane (link)

5) Dichloromethane (link)