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DCM

(Dichloromethane)


Other Names:

Methylene chloride






General Information:


Structure:



CAS Number: 75-09-2

Molecular Weight: 84.93 g/mol

Appearance: Colorless liquid

Chemical Formula: CH2Cl2

Melting Point: -95 C

Boiling Point: 40 C

Density: 1.33 g/mL




Common Uses:


Solvent for reactions





Solvent for extractions



Procedure excerpt:

…The resulting mixture was extracted with DCM (2 x 200 mL). The combined extracts were dried (Na2SO4) and concentrated…




Solvent for silica gel chromatography



Procedure excerpt:

...The crude product was purified by silica gel column chromatography (0-10% MeOH/DCM) to provide the product...




Safety:


Dichloromethane (DCM) is considered toxic and may be a carcinogen. Prolonged contact with skin can dissolve fatty tissues and cause burns. The high volatility of DCM makes it a possible inhalation hazard. DCM is only considered to be slightly flammable.




References:


1) WO2015129926, page 89

2) WO2012129338, page 134

3) WO2015051043, page 60

4) Wikipedia: Dichloromethane (link)

5) www.sigmaaldrich.com: Dichloromethane (link)