Methanesulfonyl Chloride

Other Names:

Mesyl Chloride

General Information:

Structure:

CAS Number: 124-63-0

Molecular Weight: 114.54 g/mol

Appearance: Colorless liquid

Density: 1.480 g/mL

Common Uses:

Reagent for converting alcohols to mesylates

Procedure excerpt:

To a solution of the SM (0.5 g, 2.17 mmol) in DCM (13 mL) was added TEA (0.6 mL, 4.34 mmol) and MeSO2Cl (0.2 mL, 2.6 mmol) in DCM (2 mL) at 0 C. The reaction mixture . . .

[full procedure]

Reagent for converting alcohols to chlorides

Procedure excerpt:

To a stirred solution of the SM (1.66 g, 3.05 mmol) in dry DCM (35 mL) at 0 C was added TEA (0.679 mL, 4.89 mmol) and MeSO2Cl (0.354 mL, 4.58 mmol). The reaction . . .

[full procedure]

References:

1) Patent Reference: WO2014149164, page 398, (23.7 MB)

2) Patent Reference: WO2015144799, page 327, (18.8 MB)

3) Wikipedia: Methanesulfonyl chloride (link)

4) www.sigmaaldrich.com: Methanesulfonyl chloride (link)

5) Pearson, A. J.; Roush, W. R.; Handbook of Reagents for Organic Synthesis; Activating Agents and Protecting Groups