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Methanol


Other Names:

Methyl alcohol







General Information:


Structure:



CAS Number: 67-56-1

Molecular Weight: 32.04 g/mol

Appearance: Colorless liquid

Melting Point: -98 C

Boiling Point: 64.7 C

Density: 0.791 g/mL at 25 C


Methanol is a common solvent with a wide variety of uses in organic chemistry.




Common Uses:


Reagent in Fisher esterifications





Reagent in Pinner reactions





Solvent for reactions





Solvent for silica gel chromatography



Procedure excerpt:

…The crude product was purified by silica gel column chromatography (0-10% MeOH/DCM) to provide the product…




Solvent for triturations



Procedure excerpt:

…MeOH (5 mL) and H2O (6 mL) were added to form a slurry which was stirred at RT for 1 h. The resulting solid was filtered to provide the product…




Solvent for recrystallizations



Procedure excerpt:

…purified on silica gel (0-10% EtOAc/hexane) to give a white solid. The solid was recrystallized from MeOH to provide the product…




Safety:


Methanol is considered highly toxic to humans. It is metabolized by the body to formic acid. As little as 10 mL methanol can cause permanent blindness, 30-100 mL causes death. Methanol is a highly flammable liquid.




References:


1) WO2012112946, page 43

2) WO2014149164, page 234

3) WO2011014535, page 40

4) WO2015051043, page 60

5) WO2012129344, page 132

6) WO2010045258, page 120

7) Wikipedia: Methanol (link)

8) www.sigmaaldrich.com: Methanol (link)