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NBS

(N-Bromosuccinimide)


Other Names:

1-Bromo-2,5-pyrrolidinedione






General Information:


Structure:



CAS Number: 128-08-5

Molecular Weight: 177.98 g/mol

Appearance: White solid

Melting Point: 175-180 C


N-Bromosuccinimide (NBS) is a reagent typically used in radical substitution and electrophilic addition reactions. In pure form it exists as a white solid but over time it will decompose to give off bromine which will give it a slight yellow/brown color.




Common Uses:


Reagent in SEAr (Electrophilic Aromatic Substitution) brominations




Reagent in brominations at benzylic positions




Reagent in Appel reactions





References:


1) WO2015144799, page 84

2) WO2012112946, page 165

3) WO2016014463, page 117

4) Wikipedia: N-Bromosuccinimide (link)

5) www.sigmaaldrich.com: N-Bromosuccinimide (link)