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General Information:


CAS Number: 603-35-0

Molecular Weight: 262.29 g/mol

Appearance: White solid

Triphenylphosphine is often used as a reducing agent, leading to the formation of triphenylphosphine oxide. The reaction is driven by the formation of the thermodynamically favored P=O bond of triphenylphosphine oxide. Triphenylphosphine oxide is a side-product that can be difficult to separate from desired product. Triphenylphosphine oxide is often removed through chromatography. When exposed to air, triphenylphosphine slowly oxidizes to triphenylphosphine oxide.

Common Uses:

Reagent in Mitsunobu reactions

Reagent in Appel reactions

Reagent in Staudinger reactions

Reagent for phosphonium salt preparation (usually used later in Wittig reactions)


For acute exposure triphenylphosphine is considered an irritant, for chronic exposure it poses neurological risks. Triphenylphosphine is incompatible with strong oxidizing agents.


1) Patent Reference: WO2015177325, page 70, (4.3 MB)

2) Patent Reference: WO2014152144, page 56, (4.6 MB)

3) Patent Reference: WO2015089337, page 185, (17.5 MB)

4) Patent Reference: WO2015177325, page 77, (4.3 MB)

5) Burke, S. D.; Danheiser, R. L.; Handbook of Reagents for Organic Synthesis, Oxidizing and Reducing Agents

6) Wikipedia: Triphenylphosphine (link)

7) Triphenylphosphine (link)