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Chloroform


Other Names:

Trichloromethane

Methylidyne trichloride






General Information:


Structure:



CAS Number: 67-66-3

Molecular Weight: 119.38 g/mol

Appearance: Colorless liquid

Chemical Formula: CHCl3

Melting Point: -63 C

Boiling Point: 61 C

Density: 1.489 g/mL


Chloroform (CHCl3) is a relatively common organic solvent. In most organic chemistry labs, however, methylene chloride is used as a substitute. Deuterated chloroform (CDCl3) is one of the most common NMR solvents.




Common Uses:


Solvent in bromination reactions





Solvent in manganese dioxide (MnO2) oxidations





Solvent for silica gel chromatography



Procedure excerpt:

…The crude residue was purified by silica gel column chromatography (0-1% MeOH/CHCl3) to provide the product as a light yellow solid…




Solvent for extractions



Procedure excerpt:

…was concentrated to a residue and partitioned between H2O and CHCl3. The layers were separated and the aq layer was further extracted with CHCl3 (4x)…




Safety:


Chloroform (CHCl3) is dangerous due to its ability to depress the central nervous system. In fact, chloroform was once commonly used as an anesthetic for just these CNS depressing effects. A fatal oral dose can be a small as 10 mL. Care should be taken when working with large amounts of chloroform.




References:


1) WO2014177977, page 64

2) WO2015140133, page 90

3) WO2011014535, page 46

4) WO2010104899, page 155

5) Wikipedia: Chloroform (link)

6) www.sigmaaldrich.com: Chloroform (link)