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Alcohol to Ketone

(MnO2)







Examples:


Example 1


Manganese dioxide reaction 1 - Alcohol to Ketone


A mixture of the SM (0.129 g, 0.313 mmol), MnO2 (0.807 g, 9.28 mmol), and dry DCM was stirred at RT for 16 h. The mixture was filtered through celite and the filtrate was concentrated in vacuo to provide the product as a colorless oil which was used in the next step without additional purification. [0.113 g, 86%] [UK Pat App GB2463151A, page 125]



Example 2



To a solution of the SM (100 g, 371.5 mmol) in CHCl3 (200 mL) was added MnO2 (322.9 g, 3.715 mol). The reaction mixture was stirred at 60 C for 12 h. After cooling to RT, the mixture was filtered through celite and the filtrate was concentrated in vacuo. The crude material was used in the next step without further purification. [86 g, 86%]


[Patent Reference: WO2015140133, page 90, (11.7 MB)]