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Bromine










General Information:


Structure:



CAS Number: 7726-95-6

Molecular Weight: 159.81 g/mol

Appearance: Brown/red fuming liquid

Chemical Formula: Br2

Melting Point: -7.2 C

Boiling Point: 58.8 C

Density: 3.119 g/mL


Bromine (Br2) is typically used in bromination reactions. As a fuming brown/red liquid, bromine can be difficult to handle on small or large scale. A common, easy to handle alternative to bromine is N-Bromosuccinimide (NBS).




Common Uses:


Reagent in SEAr (Electrophilic Aromatic Substitution) brominations





Reagent in brominations at alpha positions





Reagent in Appel reactions





Safety:


Bromine is a very toxic and corrosive volatile liquid. Skin contact can cause painful burns and blisters.




References:


1) WO2014177977, page 64

2) WO2011017578, page 154

3) WO2015129926, page 100

4) Wikipedia: Bromine (link)

5) Burke, S. D.; Danheiser, R. L.; Handbook of Reagents for Organic Synthesis, Oxidizing and Reducing Agents




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