New Jobs:

- Asst Professor (Brandeis)

- Radiochemist (Corteva)

- Sr Scientist (Sirrus)

- Sr Chemist (LANXESS)

Latest Internships:

- Merck

  (Chemistry)

- Corteva Agriscience

  (Organic Chemistry)



Palladium(II) Acetate


Other Names:

Palladium diacetate

bis(acetato)palladium






General Information:


Structure:



CAS Number: 3375-31-3

Molecular Weight: 224.51 g/mol

Appearance: Brown/orange solid




Common Uses:


Catalyst for Pd catalyzed couplings (ex. Suzuki)



Procedure excerpt:

A mixture of the SM (400 mg, 1.41 mmol), bis(pinacolato)diboron (1 g, 3.94 mmol), XPhos (135 mg, 0.28 mmol), Pd(OAc)2 (16 mg, 0.06 mmol), and TEA (570 mg, 5.6 mmol) . . .

[full procedure]




Catalyst for Pd catalyzed couplings (ex. Heck)



Procedure excerpt:

. . . the alkene (0.380 g, 2.48 mmol), P(o-tol)3 (0.040 g, 0.130 mmol), TEA (3 mL), and dry DMF was degassed by bubbling argon for 3 min. Pd(OAc)2 was added, argon was . . .

[full procedure]




Catalyst for Pd catalyzed couplings (ex. carbonylation)



Procedure excerpt:

The SM (50.0 g, 127 mmol) was combined with Pd(OAc)2 (5.0 g), dppp (5.0 g), and TEA (25.7 g, 254 mmol) in EtOH (1.0 L). The reaction mixture was stirred under . . .

[full procedure]




Catalyst for Pd catalyzed couplings (ex. cyanation)




Procedure excerpt:

To a solution of the SM (4.0 g, 17.46 mmol) in DMA (10 mL) was added K3[Fe(CN)6] (3.70 g, 17.5 mmol), followed by Na2CO3 (1.85 g, 17.5 mmol), then Pd(OAc)2 . . .

[full procedure]




References:


1) Patent Reference: WO2010038081, page 129, (33.8 MB)

2) UK Pat App GB2463151A, page 126

3) Patent Reference: WO2016014463, page 92, (6.7 MB)

4) Patent Reference: WO2010032200, page 133, (6.2 MB)

5) Wikipedia: Palladium(II) acetate (link)

6) www.sigmaaldrich.com: Palladium(II) acetate (link)

7) Molander, G. A.; Handbook of Reagents for Organic Synthesis, Catalyst Components for Coupling Reactions