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General Information:


CAS Number: 127-19-5

Molecular Weight: 87.12 g/mol

Appearance: Colorless liquid

Melting Point: -20 C

Boiling Point: 165 C

Density: 0.937 g/mL at 25 C

Dimethylacetamide (DMA) is a polar aprotic solvent with a high boiling point (165 C). A closely related solvent is dimethyformamide (DMF).

Common Uses:

Solvent for reactions

Procedure excerpt:

To a mixture of the SM (0.7 g, 2.86 mmol) in DMA (10 mL) was added Cs2CO3 (2.79 g, 8.59 mmol) and MeI (0.89 mL, 14.34 mmol) at RT under N2. The reaction mixture . . .

[full procedure]


DMA is a flammable liquid.


1) Patent Reference: WO2016021742, page 114, (7.7 MB)

2) Wikipedia: Dimethylacetamide (link)

3) N,N-Dimethylacetamide (link)