New Jobs:

- Scientist (AbbVie)

- Process Chemist I (Waters)

- Mfg Assoc 2 (Illumina)

- Sr Scientist II (Alvogen)

Latest Internships:

- Cyclopure

  (Chemist)

- Sarepta

  (Nucleoside Chemistry)



Bis(pinacolato)diboron


Other Names:

4,4,4',4',5,5,5',5'-Octamethyl-2,2'-bi-(1,3,2-dioxaborolane)







General Information:


Structure:




CAS Number: 73183-34-3

Molecular Wieght: 253.94 g/mol

Appearance: Colorless solid

Melting Point: 137-140 C


Bis(pinacolato)diboron is typically used for making pinacol boronate esters. These boronates are generally used subsequently in palladium catalyzed Suzuki couplings. They are also sometimes used in other reactions such as oxidations to form phenols. Pinacol boronate esters are generally easier to handle than boronic acids.




Common Uses:


Reagent for the formation of pinacol boronate esters





Reagent in the two step conversion of aryl halides to phenols





References:


1) Patent Reference: WO2010038081, page 129, (33.8 MB)

2) Patent Reference: WO2016023830, page 98, (5.1 MB)

3) Wikipedia: Bis(pinacolato)diboron (link)

4) www.sigmaaldrich.com: Bis(pinacolato)diboron (link)

5) www.tcichemicals.com: Bis(pinacolato)diboron (link)