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Dioxane


Other Names:

1,4-Dioxane

p-Dioxane






General Information:


Structure:



CAS Number: 123-91-1

Molecular Weight: 88.11 g/mol

Appearance: Colorless liquid

Melting Point: 10-12 C

Boiling Point: 100-102 C

Density: 1.034 g/mL


Dioxane is a common aprotic solvent in organic chemistry. It is an ethereal solvent which is miscible with water. Dioxane can sometimes be a useful alternative to THF when a higher boiling point is desired. Commercially available 4M HCl in dioxane is one of the most frequently encountered applications of dioxane as a solvent. The use of 4M HCl in dioxane is common for boc deprotections.


Common Uses:


Solvent for reactions





Safety:


Dioxane is irritating to the eyes and respiratory tract but has a low acute toxicity. It is considered by the EPA to be a probable human carcinogen. Dioxane is a flammable liquid.




References:


1) WO2010026121, page 36

2) Wikipedia: 1,4-Dioxane (link)

3) www.sigmaaldrich.com: 1,4-Dioxane (link)