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Alcohol to Iodide

Common Conditions:

Appel Reaction

The conversion of aliphatic alcohols to iodides is commonly carried out with iodine in the presence of PPh3 and imidazole. The mechanism is SN2 and results in the inversion of stereochemistry.

Reaction Map:

The reaction map is intended to provide insight into possible reactions one step before and after the title reaction. It also serves as an alternative way to navigate the website, and as a means of coming up with retrosynthetic ideas. Click on the reaction arrow to visit the page.