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Sodium Hydroxide


Other Names:

Caustic soda

Lye






General Information:


Structure:



CAS Number: 1310-73-2

Molecular Weight: 40.00 g/mol

Appearance: White solid

Chemical Formula: NaOH




Common Uses:


Base/reagent for the hydrolysis of esters to carboxylic acids



Procedure excerpt:

To a solution of the SM (270 mg, 1.04 mmol) in 1:1 THF/MeOH (10 mL) was added dropwise 1N NaOH (3 mL). The reaction mixture was stirred at 70 C for 2 h. . . .

[full procedure]




Base/reagent for the hydrolysis of nitriles to amides



Procedure excerpt:

A mixture of the SM (65 mg, 0.21 mmol) and NaOH (17 mg, 0.42 mmol) in 1:1 EtOH/H2O (2 mL) was stirred at 50 C for 4 h. After cooling to RT, the mixture was . . .

[full procedure]




Base/reagent for the hydrolysis of nitriles to carboxylic acids





Base/reagent for acetyl deprotections





Base/reagent for Cbz deprotections





Base in aldol condensations





Safety:


Sodium hydroxide is a strong base.




References:


1) Patent Reference: WO2014149164, page 301, (23.7 MB)

2) Patent Reference: WO2016011390, page 79, (20.2 MB)

3) Wikipedia: Sodium hydroxide (link)

4) www.sigmaaldrich.com: Sodium hydroxide (link)