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Sodium Hydroxide


Other Names:

Caustic soda

Lye






General Information:


Structure:



CAS Number: 1310-73-2

Molecular Weight: 40.00 g/mol

Appearance: White solid

Chemical Formula: NaOH




Common Uses:


Base/reagent for the hydrolysis of esters to carboxylic acids





Base/reagent for the hydrolysis of nitriles to amides





Base/reagent for the hydrolysis of nitriles to carboxylic acids





Base/reagent for acetyl deprotections





Base/reagent for Cbz deprotections





Base in aldol condensations





Safety:


Sodium hydroxide is a strong base.




References:


1) WO2014149164, page 301

2) WO2016011390, page 79

3) Wikipedia: Sodium hydroxide (link)

4) www.sigmaaldrich.com: Sodium hydroxide (link)