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Nitrile to Aldehyde

Common Conditions


Diisobutylaluminum Hydride (DIBAL-H) is the reagent of choice for the partial reduction of a nitrile to an aldehyde. The reaction is typically performed by slow addition of DIBAL-H (~1 equiv) to the nitrile at low temperatures (ex. -78 C).[1]

Rxn Map

The rxn map is intended to provide insight into common rxns that take place one step before and after the title rxn. Click on the rxn arrow to visit the page.



1) Carey, F. A.; Sundberg, R. J.; Advanced Organic Chemistry, Part B: Reactions and Synthesis