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Nitrile to Aldehyde

Common Conditions:


Diisobutylaluminum Hydride (DIBAL-H) is the reagent of choice for the partial reduction of a nitrile to an aldehyde. The reaction is typically performed by slow addition of DIBAL-H (~1 equiv) to the nitrile at low temperatures (ex. -78 C).[1]

Reaction Map:

The reaction map is intended to provide insight into possible reactions one step before and after the title reaction. It also serves as an alternative way to navigate the website, and as a means of coming up with retrosynthetic ideas. Click on the reaction arrow to visit the page.



1) Carey, F. A.; Sundberg, R. J.; Advanced Organic Chemistry, Part B: Reactions and Synthesis