Henry

Common Conditions:

Beta-Nitro Alcohol

The reaction of a nitroalkane with an aldehyde or ketone in the presence of a base provides beta-nitro alcohols. A common side reaction is the dehydration of the beta-nitro alcohol to form a nitroalkene.^[1]

Examples

Nitroalkene

Nitroalkenes are often the desired product of a Henry reaction. This usually is achieved by using elevated reaction temperatures.

Examples

Reaction Map:

The reaction map is intended to provide insight into possible reactions one step before and after the title reaction. It also serves as an alternative way to navigate the website, and as a means of coming up with retrosynthetic ideas. Click on the reaction arrow to visit the page.

For Aldehyde:





For Ketone:

References:

1) Luzio, F. A.; Tetrahedron, 2001, 57, 915-945