New Jobs:

- Scientist (AbbVie)

- Process Chemist I (Waters)

- Mfg Assoc 2 (Illumina)

- Sr Scientist II (Alvogen)

Latest Internships:

- Cyclopure


- Sarepta

  (Nucleoside Chemistry)


(Diisobutylaluminum hydride)

Other Names:



General Information:


CAS Number: 1191-15-7

Molecular Weight: 142.22 g/mol

Appearance: Colorless liquid

Diisobutylaluminum hydride (DIBAL-H) is an organoaluminum reagent typically used for the reduction esters or nitriles to aldehydes. DIBAL-H is usually obtained and used as a 1.0 M solution in a wide variety of solvents (ex. DCM, THF, hexanes, heptane, toluene, and cyclohexane). Some of the advantages of using DIBAL-H over other organoaluminum reagents include its greater selectivity, its ease of handing as a liquid, and its miscibility with a wide range of solvents (including hydrocarbons and aromatic solvents).

Common Uses:

Reagent for reducing esters to aldehydes

Reagent for reducing esters to alcohols

Reagent for reducing nitriles to aldehydes

Reagent for reducing nitriles to amines


Diisobutylaluminum hydride (DIBAL-H) reacts violently with water and moisture in the air (pyrophoric).


1) Patent Reference: WO2015140133, page 106, (11.7 MB)

2) Patent Reference: WO2015129926, page 111, (21.5 MB)

3) Diisobutylaluminum hydride (DIBAL-H) and Other Isobutyl Aluminum Alkyls (DIBAL-BOT, TIBAL) as Specialty Organic Synthesis Reagents (link)

4) Burke, S. D.; Danheiser, R. L.; Handbook of Reagents for Organic Synthesis, Oxidizing and Reducing Agents

5) Wikipedia: Diisobutylaluminium hydride (link)

6) Diisobutylaluminum hydride solution - 1.0 M in methylene chloride (link)