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IPA

(Isopropanol)


Other Names:

Isopropyl alcohol

2-Propanol

Propan-2-ol

sec-Propyl alcohol



General Information:


Structure:



CAS Number: 67-63-0

Molecular Weight: 60.10 g/mol

Appearance: Colorless liquid

Melting Point: -89 C

Boiling Point: 82 C

Density: 0.785 g/mL at 25 C


Isopropanol is used occasionally in organic chemistry as a solvent. A common use would be in reactions that require a higher boiling protic solvent. Isopropanol is also commonly used as the solvent of choice for the cold finger of a rotovap.




Common Uses:


Reagent in Meerwein-Poondorf-Verley reactions





Reagent for Mitsunobu reactions



Procedure excerpt:

PPh3 (0.55 g, 2.1 mmol) was added to a solution of the SM (0.65 g, 1.5 mmol) and IPA (0.16 mL, 2.1 mmol) in THF (7.6 mL). The mixture was cooled in an ice-H2O bath, then . . .

[full procedure]




Solvent for reactions



Procedure excerpt:

To a solution of the aryl chloride (1.0 g, 5.0 mmol) in IPA (50 mL) at RT was added the amine (817 mg, 6.0 mmol) and TEA (989 mg, 10.0 mmol). The reaction mixture . . .

[full procedure]




Solvent/co-solvent for extractions



Procedure excerpt:

. . . The aq layer was then basified with 5% aq Na2CO3 to pH ~9, and was extracted with 3:1 CHCl3/IPA (3 x 30 mL). The combined organics . . .

[full procedure]




Safety:


Isopropanol is toxic, but less toxic than methanol. Isopropanol is a flammable liquid.




References:


1) Patent Reference: WO2016011390, page 469, (20.2 MB)

2) Patent Reference: WO2014149164, page 296, (23.7 MB)

3) Patent Reference: WO2010016005, page 125, (11.3 MB)

1) Wikipedia: Isopropyl alcohol (link)

2) www.sigmaaldrich.com: 2-Propanol (link)