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Simmons-Smith

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Common Conditions:

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Et₂Zn + CH₂I₂

Simmons-Smith reactions are commonly performed with diethylzinc (Et2Zn) and diiodomethane (CH2I2) in non-coodinating solvents (ex. DCM or DCE) at RT.^[1]

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Reaction Map:

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The reaction map is intended to provide insight into possible reactions one step before and after the title reaction. It also serves as an alternative way to navigate the website, and as a means of coming up with retrosynthetic ideas. Click on the reaction arrow to visit the page.

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References:

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1) Kurti, L.; Czako, B.; Strategic Applications of Named Reactions in Organic Synthesis