New Jobs:

- Scientist (AbbVie)

- Process Chemist I (Waters)

- Mfg Assoc 2 (Illumina)

- Sr Scientist II (Alvogen)

Latest Internships:

- Cyclopure

  (Chemist)

- Sarepta

  (Nucleoside Chemistry)



AIBN

(Azobisisobutyronitrile)


Other Names:

2,2'-Azobis(2-methylpropionitrile)






General Information:


Structure:




CAS Number: 78-67-1

Molecular Weight: 164.21 g/mol

Appearance: White crystals

Melting Point: 103-104 C


Azobisisobutyronitrile (AIBN) is a common reagent for the initiation of radical reactions. AIBN decomposes at temperatures above 60 C to form isobutyronitrile radicals, which function to initiate radical chemistry. Another very common radical intiator is benzoyl peroxide.





Common Uses:


Radical initiator in benzylic brominations





Safety:


AIBN presents an explosion risk.




References:


1) Patent Reference: WO2016014463, page 101, (6.7 MB)

2) Pearson, A. J.; Roush, W. R.; Handbook of Reagents for Organic Synthesis; Activating Agents and Protecting Groups

3) Wikipedia: Azobisisobutyronitrile (link)

4) www.sigmaaldrich.com: 2,2'-Azobis(2-methylpropionitrile) (link)