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O-Demethylation

(NaSMe)







Examples:


Example 1



A mixture of the SM (3 g, 9.7 mmol) and aq NaSMe (18 mL 38.9 mmol, 21% w/v) in DMF (75 mL) was heated to 60 C for 2 h, after which time it was cooled to RT, poured into H2O (150 mL), and acidified with 1.5N HCl. The resulting solids were filtered to provide the product as an off-white solid. [2.5 g] [WO2010038081, page 122]