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  (Chemistry R&D)

- E Ink


Ketone to Difluoro



Example 1

In a plastic reaction vessel, the SM (0.57 g, 2.0 mmol) was dissolved in DCM (1 mL). To this solution was added Deoxo-Fluor (0.75 g, 3.4 mmol) followed by EtOH (0.018 g, 0.40 mmol). The reaction mixture was stirred at RT for 48 h. The mixture was quenched at RT by careful addition of sat aq NaHCO3. The material was purified by silica gel column chromatography (10-20% EtOAc/heptane) to provide the product. [212 mg, 34%]

[Patent Reference: WO2016011390, page 399, (20.2 MB)]