Alkene to Diol

Common Conditions:

OsO₄ + NMO

Osmium tetroxide (OsO4) with N-methylmorpholine N-oxide (NMO) as a co-oxidant allows only a catalytic amount of toxic OsO4 to be required. Common solvent combinations include acetone/H2O and t-BuOH/H2O.^[1][2]

Examples

Reaction Map:

The reaction map is intended to provide insight into possible reactions one step before and after the title reaction. It also serves as an alternative way to navigate the website, and as a means of coming up with retrosynthetic ideas. Click on the reaction arrow to visit the page.

References:

1) Fuchs, P. L.; Handbook of Reagents for Organic Synthesis, Catalytic Oxidation Reagents

2) Burke, S. D.; Danheiser, R. L.; Handbook of Reagents for Organic Synthesis, Oxidizing and Reducing Agents

Alkene to Diol

Common Conditions:

OsO4 + NMO

Reaction Map:

References:

OsO₄ + NMO