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Acetone


Other Names:

Propanone

Propan-2-one

2-Propanone





General Information:


Structure:



CAS Number: 67-64-1

Molecular Weight: 58.08 g/mol

Appearance: Colorless liquid

Melting Point: -94 C

Boiling Point: 56 C at 760 mmHg

Density: 0.791 g/mL at 25 C


Acetone is most commonly used in organic chemistry labs to clean glassware and make cooling baths. When combined with dry ice, acetone makes a cooling bath that has a temperature around -78 C. Acetone is miscible with water but does not form an azeotrope with water.




Common Uses:


Solvent in Jones oxidations





Reagent in reductive aminations





Reagent in Oppenauer oxidations





Safety:


Acetone is not considered to be a carcinogen, mutagenic chemical, or neurotoxin. In general, acetone is considered to be relatively safe compared to other solvents. For example, it is even used as the major component in many nail polish removers. However, care should still be taken to minimize exposure to acetone, as with all other solvents. The major danger of acetone is its high flammability. Acetone also has the ability to form highly explosive acetone peroxide in the presence of strong oxidizing reagents such as hydrogen peroxide.




References:


1) WO2011017578, page 69

2) WO2007084786, page 112

3) Wikipedia: Acetone (link)

4) www.sigmaaldrich.com: Acetone (link)

5) www.alfa.com: 22928 Acetone, HPLC Grade, 99.5% (link)

6) Kurti, L.; Czako, B.; Strategic Applications of Named Reactions in Organic Synthesis