New Jobs:

- Sr Scientist (Ionis)

- Sr Scientist (AbbVie)

- Postdoc (Los Alamos)

- Research Chemist (Optima)

Latest Internships:

- USC

  (Summer 2018)

- Kansas State

  (Summer 2018)



t-Butanol


Other Names:

t-BuOH

t-Butyl alcohol

tert-Butanol

tert-Butyl alcohol

2-Methyl-2-propanol



General Information:


Structure:



CAS Number: 75-65-0

Molecular Weight: 74.12 g/mol

Appearance: Colorless liquid

Chemical Formula: (CH3)3COH

Melting Point: 25-26 C

Boiling Point: 82-83 C

Density: 0.775 g/mL

Acidity (pKa): 16.54


t-Butanol exists in a lab environment as either a liquid or solid, depending on the ambient temperature. It finds use generally as a solvent for certain reactions, and occasionally as a reagent, as in Curtius rearrangements, for example.




Common Uses:


Reagent/solvent for Curtius rearrangement reactions that form Boc protected products





Solvent for reactions



Procedure Excerpt:

To the aryl chloride (A) (1.0 g, 4.21 mmol) and the alcohol (B) (1.77 g, 17.5 mmol) in t-BuOH (25 mL) was added NaOt-Bu (1.64 g, 16.9 mmol). The resulting mixture…




Safety:


t-Butanol is a flammable liquid.



References:


1) WO2015089337, page 151

2) WO2010038081, page 202

3) Wikipedia: tert-Butyl alcohol (link)

4) www.sigmaaldrich.com: tert-Butanol (link)

5) www.alfa.com: L12338 tert-Butyl alcohol, 99% (link)