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Sodium Bisulfite

Other Names:

Sodium hydrogen sulfite

General Information:


CAS Number: 7631-90-5

Molecular Weight: 104.061 g/mol

Appearance: White solid

Chemical Formula: NaHSO3

Melting Point: 150 C

Boiling Point: 315 C

Acidity (pKa): 6.97

Sodium bisulfite (NaHSO3) is a weakly acidic compound that is usually used as a mild reducing agent. Sodium bisulfite is typically used as an aqueous solution. A common application is in the workup of reactions involving bromine or iodine.

Common Uses:

Mild reducing agent for bromine or iodine reaction workups (ex. bromination or iodination)

Procedure excerpt:

. . . The mixture was stirred at RT for 1 h, after which time it was poured into ice/H2O (30 mL) containing NaHSO3 (257 mg, 2.46 mmol). The reaction was . . .

[full procedure]

Mild reducing agent for Jones oxidation workups

Procedure excerpt:

. . . The mixture was diluted with ether (600 mL) and washed with 2% aq NaHSO3 (5 x 100 mL). The layers were separated and the aq layer was . . .

[full procedure]


1) Patent Reference: WO2012129338, page 84, (12.0 MB)

2) Patent Reference: WO2011017578, page 69, (8.3 MB)

3) Wikipedia: Sodium bisulfite (link)

4) Sodium bisulfite (link)