New Jobs:

- Assoc RS (Exelixis)

- Org/Med Chemist (Flavine)

- Process Chemist (Avista)

- Sr Chemist (Laxmi)

Latest Internships:

- Theravance

  (Medicinal Chemistry)

- Cepheid


Oxalyl Chloride

Other Names:

Ethanedioyl dichloride

General Information:


CAS Number: 79-37-8

Molecular Weight: 126.93 g/mol

Appearance: Colorless liquid

Melting Point: -12 C

Boiling Point: 63-64 C

Density: 1.48 g/mL

Common Uses:

Reagent for the conversion of carboxylic acids to acid chlorides

Reagent in Swern Oxidations (converts alcohols to aldehydes or ketones)


Oxalyl chloride is very toxic and corrosive. It is severely irritating to eyes, skin, and the respiratory tract. Oxalyl chloride reacts violently with water.


1) Patent Reference: WO2010038081, page 138, (33.8 MB)

2) Patent Reference: WO2012129338, page 85, (12.0 MB)

3) Patent Reference: WO2010016005, page 120, (11.3 MB)

4) Patent Reference: WO2016011390, page 112, (20.2 MB)

5) Wikipedia: Oxalyl chloride (link)

6) Oxalyl chloride (link)

7) Pearson, A. J.; Roush, W. R.; Handbook of Reagents for Organic Synthesis; Activating Agents and Protecting Groups