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DMSO

(Dimethyl sulfoxide)


Other Names:

Methyl sulfoxide






General Information:


Structure:



CAS Number: 67-68-5

Molecular Weight: 78.13 g/mol

Appearance: Colorless liquid

Melting Point: 16-19 C

Boiling Point: 189 C

Density: 1.10 g/mL


Dimethyl sulfoxide (DMSO) is a polar aprotic solvent that can dissolve a wide range of organic compounds. The high dissolving power of DMSO makes deuterated DMSO (DMSO-d6) a common solvent for NMR. One of the major drawbacks of DMSO is the difficulty of removal after a reaction. Its high boiling point (189 C) makes removal by rotovap very difficult. DMSO is also used as a reagent in a variety of different reactions.




Common Uses:


Reagent in Swern oxidations (conversion of alcohols to their corresponding ketones or aldehydes)






Safety:


DMSO readily penetrates the skin.




References:


1) WO2016011390, page 112

2) WO2010016005, page 120

3) Wikipedia: Dimethyl sulfoxide (link)

4) www.sigmaaldrich.com: Dimethyl sulfoxide (link)