NMP

(N-Methyl-2-pyrrolidone)

Other Names:

1-Methyl-2-pyrrolidone

General Information:

Structure:

CAS Number: 872-50-4

Molecular Weight: 99.13 g/mol

Appearance: Colorless liquid

Melting Point: -24 C

Boiling Point: 202 C

Density: 1.028 g/mL at 25 C

NMP is a polar aprotic solvent with similar solvent properties as DMF, DMA, and DMSO. NMP is miscible with water.

Common Uses:

Solvent for reactions

Procedure excerpt:

To a 15 C solution of the aryl chloride (220 g, 860.37 mmol) and the amine (137.7 g, 1.03 mol) in NMP (3.6 L) was added DIEA (450 mL, 2.58 mol). The resulting mixture . . .

[full procedure]

Safety:

NMP is a reproductive toxicant but has relatively low overall toxicity. NMP has relatively low flammability.

References:

1) Patent Reference: WO2014110000, page 19, (2.6 MB)

2) Wikipedia: N-Methyl-2-pyrrolidone (link)

3) www.sigmaaldrich.com: 1-Methyl-2-pyrrolidinone (link)