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Formaldehyde


Other Names:

Formalin

Methanal

Methyl aldehyde





General Information:


Structure:



CAS Number: 50-00-0

Molecular Weight: 30.03 g/mol

Appearance: Colorless gas (at room temperature)


Formaldehyde is the simplest aldehyde.




Common Uses:


Reagent for reductive methylation (reductive amination) of amines





Reagent in Pictet-Spengler reactions





Reagent in the hydroxymethylation of Grignard reagents to give primary alcohols




Safety:


Formaldehyde is a known carcinogen and is highly toxic to all animals.




References:


1) WO2016011390, page 65

2) WO2016014463, page 91

3) Coates, R. M.; Denmark, S. E.; Handbook of Reagents for Organic Synthesis, Reagents, Auxiliaries, and Catalysts for C-C Bond Formation

4) Wikipedia: Formaldehyde (link)

5) www.sigmaaldrich.com: Formaldehyde solution - 37 wt. % in H2O (link)