Pictet-Spengler

(Formaldehyde)

Examples:

Example 1

A solution of the SM (165 g, 1.0 mol) and aq formaldehyde (37 wt%, 30 g, 1.0 mol) in formic acid (1.5 L) was stirred at 50 C overnight. The solvent was removed in vacuo to provide the product which was taken on to the next step without further purification. [150 g]

[Patent Reference: WO2016014463, page 91, (6.7 MB)]