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Pictet-Spengler

(Formaldehyde)







Examples:


Example 1



A solution of the SM (165 g, 1.0 mol) and aq formaldehyde (37 wt%, 30 g, 1.0 mol) in formic acid (1.5 L) was stirred at 50 C overnight. The solvent was removed in vacuo to provide the product which was taken on to the next step without further purification. [150 g]


[Patent Reference: WO2016014463, page 91, (6.7 MB)]