Pd(PPh₃)₂Cl₂

[Bis(triphenylphosphine)palladium(II) Dichloride]

Other Names:

Dichlorobis(triphenylphosphine)palladium(II)

Bis(triphenylphosphine)dichloropalladium(II)

Palladium(II)bis(triphenylphosphine) dichloride

trans-Dichlorobis(triphenylphosphine)palladium(II)

General Information:

Structure:

CAS Number: 13965-03-2

Molecular Weight: 701.90 g/mol

Appearance: Yellow solid

Pd(PPh3)2Cl2 is a catalyst commonly employed in palladium catalyzed reactions such as Suzuki reactions, Sonogashira reactions, Heck reactions, etc. Pd(PPh3)2Cl2 is generally more stable at room temperature and has a longer shelf-life than Pd(PPh3)4.

Common Uses:

Catalyst in palladium catalyzed reactions (ex. Suzuki)

Procedure excerpt:

. . . then N2 was bubbled through the mixture. Pd(Ph3)2Cl2 (0.008 g, 0.012 mmol) was added and the mixture was flushed again with N2. The reaction mixture was . . .

[full procedure]

Catalyst in palladium catalyzed reactions (ex. Sonogashira)

Procedure excerpt:

A mixture of the bromide (0.976 g, 5 mmol), Pd(PPh3)2Cl2 (0.106 g, 0.15 mmol), DIEA (0.646 g, 5 mmol), and CuI (0.095 g, 0.5 mmol) in DMF was purged with . . .

[full procedure]

References:

1) Patent Reference: WO2012149280, page 80, (4.1 MB)

2) Patent Reference: WO2010016005, page 86, (11.3 MB)

3) Wikipedia: Bis(triphenylphosphine)palladium chloride (link)

4) www.sigmaaldrich.com: Bis(triphenylphosphine)palladium(II) dichloride (link)

5) www.alfa.com: 10491 trans-Dichloro(triphenylphosphine)palladium(II), Pd 14.0% min (link)

6) www.strem.com: trans-Dichloro(triphenylphosphine)palladium(II), 99% (99.9+%-Pd) (link)

7) Molander, G. A.; Handbook of Reagents for Organic Synthesis, Catalyst Components for Coupling Reactions