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HOBt

(Hydroxybenzotriazole)


Other Names:

Benzotriazol-1-ol

N-Hydroxybenzotriazole





General Information:


Structure:



CAS Number: 2592-95-2 (anhydrous)

    123333-53-9 (hydrate)

Molecular Weight: 135.13 g/mol (anhydrous)

    153.14 g/mol (mono-hydrate)

Appearance: White crystalline powder




Common Uses:


Reagent for amide couplings (EDC + HOBt)





Safety:


Hydroxybenzotriazole (HOBt) is potentially explosive, especially in anhydrous form.




References:


1) WO2014149164, page 227

2) Wikipedia: Hydroxybenzotriazole (link)

3) www.sigmaaldrich.com: 1-Hydroxybenzotriazole hydrate (link)

2) Pearson, A. J.; Roush, W. R.; Handbook of Reagents for Organic Synthesis, Activating Agents and Protecting Groups