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HOBt

(Hydroxybenzotriazole)


Other Names:

Benzotriazol-1-ol

N-Hydroxybenzotriazole





General Information:


Structure:



CAS Number: 2592-95-2 (anhydrous)

    123333-53-9 (hydrate)

Molecular Weight: 135.13 g/mol (anhydrous)

    153.14 g/mol (mono-hydrate)

Appearance: White crystalline powder




Common Uses:


Reagent for amide couplings (EDC + HOBt)



Procedure excerpt:

To a solution of the SM (1.0 g, 6.4 mmol) in DMF (5.0 mL) at 0 C was added EDC-HCl (1.2 g, 7.7 mmol), NH4Cl (1.4 g, 26.9 mmol), and HOBt (1.1 g, 8.3 mmol). The reaction . . .

[full procedure]




Safety:


Hydroxybenzotriazole (HOBt) is potentially explosive, especially in anhydrous form.




References:


1) Patent Reference: WO2014149164, page 227, (23.7 MB)

2) Wikipedia: Hydroxybenzotriazole (link)

3) www.sigmaaldrich.com: 1-Hydroxybenzotriazole hydrate (link)

2) Pearson, A. J.; Roush, W. R.; Handbook of Reagents for Organic Synthesis, Activating Agents and Protecting Groups