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Urea Formation

(CDI)







Examples:


Example 1



To a solution of A (80 mg, 0.24 mmol) in DMF (2 mL) was added TEA (48 mg, 0.48 mmol). The mixture was stirred at RT for 10 min, after which time was added CDI (39 mg, 0.24 mmol). The mixture was stirred at RT for 1 h, after which time was added B (48 mg, 0.48 mmol). The reaction mixture was stirred at RT for an additional 12 h. The mixture was purified by Prep-HPLC to provide the product as a yellow solid. [68 mg, 52%] [WO2015089337, page 98]