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Nitrile to Amine

(H₂ + Pd/C)

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Examples:

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Example 1

A mixture of the SM (45 mg, 0.12 mmol) and Pd/C (5 mg) in 4:1 THF/NH4OH (2.5 mL) was stirred under H2 at RT for 1 h. The reaction mixture was filtered, concentrated, and purified by Prep HPLC [5-95% (MeOH)/(H2O with 0.05% NH4OH)] to provide the product as a white solid. [10 mg, 22%]

[Patent Reference: WO2016011390, page 152, (20.2 MB)]