1. Home
2. Benzyl Protection

Benzyl Protection

---

Common Conditions (Protection):

---

BnBr

Benzyl protection is typically performed using benzyl bromide (BnBr) or benzyl chloride (BnCl) in the presence of a base.^[1][2]

---

Common Conditions (Deprotection):

---

H₂ + Pd/C

Catalytic hydrogenolysis it the most common method of benzyl deprotection. Typical solvents include (MeOH, EtOH, EtOAc, and THF).^[1][2]

---

References:

---

1) Kocienski, P. J.; Protecting Groups, 3rd Edition

2) Wuts, P. G. M.; Greene, T. W.; Greene's Protective Groups in Organic Synthesis, 4th Edition