New Jobs:

- Research Inv II (BMS)

- Mgr - Chem Dev (Sage)

- Assoc Scientist (Mosaic)

- Sr Scientist (TPC Group)

Latest Internships:

- DAAD RISE - Germany

  (Summer Internship)

- ACS DOC SURF

  (Organic Chemistry)



Benzyl Protection








Common Conditions (Protection):


BnBr

Benzyl protection is typically performed using benzyl bromide (BnBr) or benzyl chloride (BnCl) in the presence of a base.[1][2]






Common Conditions (Deprotection):


H2 + Pd/C

Catalytic hydrogenolysis it the most common method of benzyl deprotection. Typical solvents include (MeOH, EtOH, EtOAc, and THF).[1][2]






References:


1) Kocienski, P. J.; Protecting Groups, 3rd Edition

2) Wuts, P. G. M.; Greene, T. W.; Greene's Protective Groups in Organic Synthesis, 4th Edition