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Benzyl Protection

Common Conditions (Protection):


Benzyl protection is typically performed using benzyl bromide (BnBr) or benzyl chloride (BnCl) in the presence of a base.[1][2]

Common Conditions (Deprotection):

H2 + Pd/C

Catalytic hydrogenolysis it the most common method of benzyl deprotection. Typical solvents include (MeOH, EtOH, EtOAc, and THF).[1][2]


1) Kocienski, P. J.; Protecting Groups, 3rd Edition

2) Wuts, P. G. M.; Greene, T. W.; Greene's Protective Groups in Organic Synthesis, 4th Edition