New Jobs:

- Sr Scientist (Ionis)

- Sr Scientist (AbbVie)

- Postdoc (Los Alamos)

- Research Chemist (Optima)

Latest Internships:


  (Summer 2018)

- Kansas State

  (Summer 2018)

Benzyl Bromide

Other Names:



General Information:


CAS Number: 100-39-0

Molecular Weight: 171.03 g/mol

Appearance: Colorless liquid

Melting Point: -4 C

Boiling Point: 201 C

Density: 1.438 g/mL at 25 C

Benzyl bromide is typically used for installing benzyl protecting groups on alcohols and amines. Benzyl bromide is a strong lachrymator and should be handled in a fume hood. Concentrating reaction mixtures on rotovaps that are not in a fume hood can lead to enough exposure for the irritating effects to be noticed. Purifying crude reaction material on automated purification machines outside a fume hood can also provide sufficient exposure to notice the effects (irritated eyes, coughing, etc.).

Common Uses:

Reagent in the benzyl protection of amines

Reagent in the benzyl protection of alcohols


Benzyl bromide is a severe irritant to the eyes, mucous membranes (mouth, throat, lungs, etc.), and skin. Exposure can cause intense pain and irritation of the eyes, nose, and throat similar to the effects of tear gas. Difficulty with breathing may result temporarily. Acute exposure may be fatal. Permanent eye damage can result from a large exposure. Benzyl bromide is a combustible liquid.


1) WO2014149164, page 232

2) WO2016014463, page 105

3) Wikipedia: Benzyl bromide (link)

4) Benzyl bromide (link)

5) A13535 Benzyl bromide, 99% (link)

6) Pearson, A. J.; Roush, W. R.; Handbook of Reagents for Organic Synthesis; Activating Agents and Protecting Groups

Related Books: