New Jobs:

- Med Chemist (SBP)

- Scientist (Astex)

- Sr Scientist (Casma)

- Org Chemist (Fraunhofer)

Latest Internships:

- U of Florida/France

  (Summer 2019)

- University of Iowa

  (Summer 2019)



Potassium Carbonate










General Information:


Structure:



CAS Number: 584-08-7

Molecular Weight: 138.21 g/mol

Appearance: White solid

Chemical Formula: K2CO3

Melting Point: 891 C


Potassium carbonate (K2CO3) is a commonly used base in organic chemistry. The pKa of its conjugate acid is 10.25. It is commonly used to deprotonate moderately acidic protons such as phenols (pKa ~10) and 1,3-dicarbonyl compounds (pKa ~9-13). Potassium carbonate has high solubility in water (1.12 g/mL, at 20 C), and has low solubility in ethanol, acetone, and many other common organic solvents.




Common Uses:


- Base for alkylations (including Benzyl Protections, SEM Protections, and Cbz Protections)

- Base for Pd Coupling reactions

- Base to neutralize acidic reaction mixtures prior to workup




Safety:


Potassium carbonate is considered a weak base. Avoid contact with skin and eyes. Potassium carbonate is relatively non-toxic.




References:


1) Wikipedia: Potassium carbonate (link)

2) www.sigmaaldrich.com: Potassium carbonate (link)

3) Reich, H. J.; Rigby, J. H.; Handbook of Reagents for Organic Synthesis, Acidic and Basic Reagents