Alkylbenzene to Acid

Common Conditions:

KMnO₄

The oxidation of alkylbenzenes to carboxylic acids is typically carried out with potassium permanganate (KMnO4). KMnO4 is soluble in H2O, as a result reactions are usually carried out in H2O or a mixture of H2O and a miscible organic solvent (ex. AcOH, ACN, or pyridine).^[1]

Examples

Reaction Map:

The reaction map is intended to provide insight into possible reactions one step before and after the title reaction. It also serves as an alternative way to navigate the website, and as a means of coming up with retrosynthetic ideas. Click on the reaction arrow to visit the page.

References:

1) Burke, S. D.; Danheiser, R. L.; Handbook of Reagents for Organic Synthesis, Oxidizing and Reducing Agents