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Alkene to Alkane



Example 1

A mixture of the SM (1.38 g, 5 mmol), Zn dust (1.95 g, 30 mmol), NH4Cl (2.67 g, 50 mmol), MeOH (10 mL), and H2O (5 mL) were refluxed for 4 h. The mixture was cooled to RT, filtered, and the filtrate concentrated. The resulting residue was purified by chromatography (5:1 PE/EtOAc) to provide the product as a brown solid. [1.15 g, 83%]

[Patent Reference: WO2016023832, page 71, (3.2 MB)]