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Alcohol to Methylene

(Et3SiH + TFA)


Example 1

To a solution of the SM (30 mg, 0.047 mmol) in TFA (2 mL) was added Et3SiH (1 mL). The reaction mixture was stirred at RT for 3 h, then diluted with DCM (5 mL) and H2O (5 mL). The org layer was dried (Na2SO4) and concentrated to provide the product as an oil. [25 mg, 83.9%]

[Patent Reference: WO2016023832, page 41, (3.2 MB)]