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Alcohol to Methylene

Common Conditions:

Et3SiH + TFA

Alcohols that are capable of being ionized in trifluoroacetic acid (TFA) can be reduced to their corresponding alkanes by hydride transfer from the Si-H bond in triethylsilane (Et3SiH).[1]

Reaction Map:

The reaction map is intended to provide insight into possible reactions one step before and after the title reaction. It also serves as an alternative way to navigate the website, and as a means of coming up with retrosynthetic ideas. Click on the reaction arrow to visit the page.



1) Carey, F. A.; Sundberg, R. J.; Advanced Organic Chemistry, Part B: Reactions and Synthesis