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Alcohol to Fluoride



Example 1

The SM (50 mg, 0.135 mmol) was dissolved in anhydrous DCM (2 mL), and the mixture was cooled to 0 C. Deoxo-Fluor (0.074 mL, 0.404 mmol) was added dropwise, the reaction mixture was stirred at 0 C for 1 h, and then allowed to reach RT over 14 h. The mixture was quenched with MeOH (1 mL) and the solvent was removed in vacuo. The residue was purified by flash chromatography to provide the product as a white solid. [50 mg, 99%]

[Patent Reference: WO2016010950, page 209, (18.8 MB)]