New Jobs:

- Sr Scientist (Ionis)

- Sr Scientist (AbbVie)

- Postdoc (Los Alamos)

- Research Chemist (Optima)

Latest Internships:

- USC

  (Summer 2018)

- Kansas State

  (Summer 2018)



Acid to Alcohol

(BH3-SMe2)







Examples:


Example 1


Alcohol to Ester reaction 6


To a solution of the SM (1.0 g, 6.4 mmol) in THF (18 mL) at 0 C was added BH3-SMe2 (6.4 mL, 12.8 mmol). The reaction mixture was stirred at 0 C for 2 h then RT for 3 h. The mixture was then cooled to 0 C and quenched with sat aq K2CO3 (5 mL). The layers were separated and the aq layer was extracted with EtOAc (2 x 15 mL) and diethyl ether (2 x 15 mL). The combined org layers were dried (Na2SO4), filtered, and concentrated to provide the product as a colorless oil [1.0 g, 100 %]. [WO2011061214, page 87]