New Jobs:

- Scientist (MilliporeSigma)

- Sr Chemist (Nanoly)

- Research Assoc (Gilead)

- Sr RS (Saimerak Pharma)

Latest Internships:

- Moderna

  (Discovery Chemistry)

- Merck

  (Chemistry)



Trimethylsilyl diazomethane


Other Names:

(Diazomethyl)trimethylsilane

Diazo(trimethylsilyl)methane




General Information:


Structure:



CAS Number: 18107-18-1

Molecular Weight: 114.22 g/mol

Appearance: Greenish-yellow liquid




Common Uses:


Reagent for the conversion of carboxylic acids to methyl esters



Procedure excerpt:

Trimethylsilyldiazomethane (2.0M in hexane, 25 mL, 50 mmol) was added dropwise to a 0 C solution of the SM (4.64 g, 41.4 mmol) in DCM (25 mL) and MeOH (5 mL). . . .

[full procedure]




References:


1) Patent Reference: WO2015129926, page 108, (21.5 MB)

2) Wikipedia: Trimethylsilyldiazomethane (link)

3) www.sigmaaldrich.com: (Trimethylsilyl)diazomethane solution (link)