TFAA

(Trifluoroacetic Anhydride)

General Information:

Structure:

CAS Number: 407-25-0

Molecular Weight: 210.03 g/mol

Appearance: Colorless liquid

Common Uses:

Reagent for the conversion of amides to nitriles

Procedure excerpt:

To a solution of the SM (1.0 g, 4 mmol) in dry DCM (20 mL) at 0 C was added TEA (3.1 g, 31.0 mmol), followed by TFAA (4.1 g, 20.0 mmol). The resulting mixture was . . .

[full procedure]

Safety:

Trifluoracetic anhydride (TFAA) is a corrosive, moisture sensitive liquid. TFAA is toxic by inhalation.

References:

1) Patent Reference: WO2014149164, page 214, (23.7 MB)

2) Wikipedia: Trifluoroacetic anhydride (link)

3) www.sigmaaldrich.com: Trifluoroacetic anhydride (link)

4) Pearson, A. J.; Roush, W. R.; Handbook of Reagents for Organic Synthesis, Activating Agents and Protecting Groups