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(Trifluoroacetic Anhydride)

General Information:


CAS Number: 407-25-0

Molecular Weight: 210.03 g/mol

Appearance: Colorless liquid

Common Uses:

Reagent for the conversion of amides to nitriles


Trifluoracetic anhydride (TFAA) is a corrosive, moisture sensitive liquid. TFAA is toxic by inhalation.


1) Patent Reference: WO2014149164, page 214, (23.7 MB)

2) Wikipedia: Trifluoroacetic anhydride (link)

3) Trifluoroacetic anhydride (link)

4) Pearson, A. J.; Roush, W. R.; Handbook of Reagents for Organic Synthesis, Activating Agents and Protecting Groups