New Jobs:

- Scientist (Ribometrix)

- Sr Scientist (Goldfinch Bio)

- Scientific Leader (GSK)

- Chemistry RA (DiCE)

Latest Internships:

- Cayman Chemical

  (Bio-Organic Chemistry)

- Complete Genomics


Phosphorus Oxychloride

Other Names:

Phosphoryl chloride

Phosphoryl trichloride

Phosphorus(V) oxide chloride

General Information:


CAS Number: 10025-87-3

Molecular Weight: 153.33 g/mol

Appearance: Colorless liquid

Chemical Formula: POCl3

Melting Point: 1.25 C

Boiling Point: 105.8 C

Density: 1.645 g/mL

Common Uses:

Reagent for the formation of active chloro-heterocycles

Reagent for the dehydration of unsubstituted amides to nitriles

Reagent in Bischler-Napieralski reactions


Phosphorus oxychloride (POCl3) is very toxic and reacts strongly with water.


1) Patent Reference: WO2007117607, page 307, (12.9 MB)

2) Patent Reference: WO2010031852, page 37, (2.8 MB)

3) Patent Reference: WO2016014463, page 94, (6.7 MB)

4) Wikipedia: Phosphoryl chloride (link)

5) Phosphorus(V) oxychloride (link)

6) Pearson, A. J.; Roush, W. R.; Handbook of Reagents for Organic Synthesis; Activating Agents and Protecting Groups