HATU

Other Names:

1-[Bis(dimethylamino)methylene]-1H-1,2,3-

triazolo[4,5-b]pyridinium 3-oxid

hexafluorophosphate

General Information:

Structure:

CAS Number: 148893-10-1

Molecular Weight: 380.23 g/mol

Appearance: White crystalline solid

Melting Point: 183-185 C

Common Uses:

Reagent for amide coupling reactions

Procedure excerpt:

A mixture of the acid (3.00 g, 21.1 mmol), the amine (2.09 mL, 21.1 mmol), DIEA (10.5 mL, 63.3 mmol), and HATU (8.03 g, 21.1 mmol) in DMF (130 mL) was stirred . . .

[full procedure]

References:

1) Patent Reference: WO2016012477, page 162, (8.1 MB)

2) Wikipedia: HATU (link)

3) www.sigmaaldrich.com: HATU (link)