New Jobs:

- Postdoctoral RA (UNC)

- Org Chemist (Ecolectro)

- Sr/Prin RA (FORMA)

- RS I - Chem Dev (AMRI)

Latest Internships:

- Roche

  (Medicinal Chemistry)

- Takeda

  (Chemistry)



HATU


Other Names:

1-[Bis(dimethylamino)methylene]-1H-1,2,3-

    triazolo[4,5-b]pyridinium 3-oxid

    hexafluorophosphate





General Information:


Structure:



CAS Number: 148893-10-1

Molecular Weight: 380.23 g/mol

Appearance: White crystalline solid

Melting Point: 183-185 C




Common Uses:


Reagent for amide coupling reactions



Procedure excerpt:

A mixture of the acid (3.00 g, 21.1 mmol), the amine (2.09 mL, 21.1 mmol), DIEA (10.5 mL, 63.3 mmol), and HATU (8.03 g, 21.1 mmol) in DMF (130 mL) was stirred . . .

[full procedure]




References:


1) Patent Reference: WO2016012477, page 162, (8.1 MB)

2) Wikipedia: HATU (link)

3) www.sigmaaldrich.com: HATU (link)