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DIAD

(Diisopropyl Azodicarboxylate)


Other Names:

Diisopropyl azodiformate






General Information:


Structure:



CAS Number: 2446-83-5

Molecular Weight: 202.21 g/mol

Melting Point: 3-5 C

Boiling Point: 75 C

Density: 1.027 g/mL


Diisopropyl azodicarboxylate (DIAD) is typically used for Mitsunobu reactions. Similar reagents to DIAD include DEAD, DtBAD, and ADDP. DIAD is quickly replacing Diethyl azodicarboxylate (DEAD) as the preferred azodicarboxylate due to the known safety concerns of DEAD.




Common Uses:


Reagent for Mitsunobu reactions





References:


1) Patent Reference: WO2016011390, page 469, (20.2 MB)

2) Wikipedia: Diisopropyl azodicarboxylate (link)

3) www.sigmaaldrich.com: Diisopropyl azodicarboxylate (link)